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Literature Print E-mail
Enzyme zerstören die Hautoberfläche 

Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions

Reduction of skin barrier function by proteolitic activity of a recombinant house dust mite myjor allergen DER f 1

Enzyme verstärken die Immunantwort

Recombinant Der p1 and Der f 1 with in vitro enzymatic activity to cleave human CD 23 (IgE-rec) CD 25 (IL-2_rec) and alpha1-antitripsin, and in vivo IgE-eliciting activity in mice
Proteolitic activity of the house dust mite allergen Der p1 enhances allergenicity in a mouse inhalation model


Further reading:

Adam, E., K. K. Hansen, et al. (2006). The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. J Biol Chem 281(11): 6910-23.

AHA! News 2, Juni 2005

Anibarro, B., Bausela, J., Fontela L. (1996). Occupational asthma in a cheese worker. Allergy 51(12): 960-1

Atanackovic, D. (1972). Allergic respiratory diseases due to enzymatic laundry detergents (comprehensive review). Plucne Bolesti Tuberk 24(3): 240-3.

Bernstein, I. L. (1972). Enzyme allergy in populations exposed to long-term, low-level concentrations of household laundry products. J Allergy Clin Immunol 49(4): 219-37.

C.E. Kuehni, F. H. Sennhauser: Asthma-Epidemiologie: Prävalenz, zeitliche Trends, natürlicher Verlauf; Schweiz Med Forum 2002; Nr. 18, 421-23.

Cullinan, P., J. M. Harris, et al. (2000). An outbreak of asthma in a modern detergent factory. Lancet 356(9245): 1899-900

Deleuran, M., A. R. Ellingsen, et al. (1998). Purified Der p1 and p2 patch tests in patients with atopic dermatitis: evidence for both allergenicity and proteolytic irritancy. Acta Derm Venereol 78(4): 241-3.

Falleroni, A. E. and D. P. Schwartz (1971). Immediate hypersensitivity to enzyme detergents. Lancet 1(7698): 548.

Hole, A. M., A. Draper, et al. (2000). Occupational asthma caused by bacillary amylase used in the detergent industry. Occup Environ Med 57(12): 840-2.

Kanerva, L. and M. Vanhanen (2001). Occupational allergic contact urticaria and rhinoconjunctivitis from a detergent protease. Contact Dermatitis 45(1): 49-51.

M.Bruze et al. (1987). Contact allergy to the active ingredients of Kathon CG in the guinea pig. Acta Derm.Venereol., 67, 315-320.

M.Bruze et al. (1987). Contact allergy to the active ingredients of Kathon CG. Contact Dermatitis 16, 183-188.

Niinimaki, A. and S. Saari (1978). Dermatological and allergic hazards of cheesemakers. Scand J Work Environ Health 4(3): 262-3.

Poley, J. R. (1988). Loss of the glycocalyx of enterocytes in small intestine: a feature detected by scanning electron microscopy in children with gastrointestinal intolerance to dietary protein. J Pediatr Gastroenterol Nutr 7(3): 386-94.

Roche, N., T. C. Chinet, et al. (1997). Allergic and nonallergic interactions between house dust mite allergens and airway mucosa. Eur Respir J 10(3): 719-26.

Rosenman, K.:(2006): Cleaning-Products-Related Asthma, Obstructive Airway Disease, Clinical Pulmonary Medicine. 13(3):221-228.

Sen, D., K. Wiley, et al. (1998). Occupational asthma in fruit salad processing. Clin Exp Allergy 28(3): 363-7.

Sun, G., M. A. Stacey, et al. (2001). Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J Immunol 167(2): 1014-21.

Takai, T., T. Kato, et al. (2005). Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice. Int Arch Allergy Immunol 137(3): 194-200.

Wan, H., H. L. Winton, et al. (1999). Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 104(1): 123-33.

Wüthrich, B. (1994). Enzymes: potent inhalant and ingestive allergens--obligation of declaration lacking in bakery products and flour. Schweiz Med Wochenschr 124(31-32): 1361-3.

Wüthrich, B. and X. Baur (1990). Baking ingredients, especially alpha-amylase, as occupational inhalation allergens in the baking industry. Schweiz Med Wochenschr 120(13): 446-50

Wüthrich, B. and F. Ott (1969). Occupational asthma due to proteases in the detergent industry. Schweiz Med Wochenschr 99(44): 1584-6.